Two sample MR report
HLA-DQB1_Dendritic Cell (DC) against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 16 | -0.0305303 | 0.1330509 | 0.8218274 |
| Weighted median | 16 | -0.0515999 | 0.0212208 | 0.0150334 |
| Inverse variance weighted | 16 | -0.0342717 | 0.0169470 | 0.0431470 |
| Simple mode | 16 | -0.0554831 | 0.0343337 | 0.1269282 |
| Weighted mode | 16 | -0.0546438 | 0.0338626 | 0.1274299 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 4.610080 | 14 | 0.9905338 |
| Inverse variance weighted | 4.610883 | 15 | 0.9949397 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0020526 | 0.0723981 | 0.9777824 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004431 | 0 | TRUE | 0.0451469 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
